|
Unipolar Depression
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs.
|
25944848 |
2015 |
|
Thyroid associated opthalmopathies
|
0.010 |
Biomarker
|
disease |
BEFREE |
The sst(2) transcript was found in nine, sst(3) in five and sst(5) in eight out of ten GO cell cultures.
|
10915219 |
2000 |
|
testicular nonseminoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, they further indicate that the presence of sst1 and sst3 transcripts might be used as an additional criterion to distinguish between seminoma and nonseminoma tumors.
|
11718451 |
2001 |
|
Squamous cell carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The comparison of the three tumour entities revealed that SCLC samples had higher SST2, SST5, and CXCR4 expression, but lower SST3 and SST1 relative to ADC or SQC samples.
|
30076481 |
2018 |
|
Seminoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Altogether these data indicate that: (i) normal human testes are putative SRIF targets; (ii) loss of sst3 and sst4 SRIF receptor expression might be associated with seminoma carcinogenesis.
|
10753219 |
2000 |
|
Seminoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Moreover, they further indicate that the presence of sst1 and sst3 transcripts might be used as an additional criterion to distinguish between seminoma and nonseminoma tumors.
|
11718451 |
2001 |
|
Secondary Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Using reverse transcription-PCR, we investigated gene expression of the five receptors in 47 human normal and cancerous tissues or cell lines from pancreatic and colorectal origin. mRNAs of somatostatin receptor subtypes were detected in 98% of samples, with more than two mRNA subtypes being expressed in 55% of cases. sst1, sst4, and sst5 were heterogeneously expressed in both normal and cancerous tissues; sst3 was rarely or not expressed. sst2 was present in normal pancreatic tissues but was absent in exocrine pancreatic carcinomas and their metastases. sst2 mRNAs were detected in normal colon, sporadic polyadenomas, and 50% of Dukes' stage B and 20% of Dukes' stage C carcinomas but were undetectable in Dukes' stage D carcinomas, hepatic metastases, and adenomas from familial adenomatous polyposis.
|
8620499 |
1996 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs.
|
25944848 |
2015 |
|
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy.
|
31095341 |
2020 |
|
Pituitary Adenoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
A Critical Evaluation of sst3 and sst5 Immunohistochemistry in Human Pituitary Adenomas.
|
28384628 |
2018 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, in diabetes and obesity, the mechanisms involved in reducing the transactivation of the insulin response sequence by IRE-BP1 include decreased gene transcription and nuclear exclusion to prevent DNA binding.
|
18566119 |
2008 |
|
Non-Functioning Pituitary Gland Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
A somatostatin receptor subtype-3 (SST3) peptide agonist shows antitumor effects in experimental models of Nonfunctioning Pituitary Tumors.
|
31624102 |
2020 |
|
Neuroendocrine Tumors
|
0.010 |
Biomarker
|
group |
BEFREE |
The five receptors bind the natural peptide with high affinity but only sst2, sst5 and sst3 bind the short synthetic analogues used to treat patients with neuroendocrine tumors.
|
10940684 |
2000 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
VEGF and tumor vascularization were identified as novel targets for sst2-mediated antitumoral bystander effect. sst3 somatostatin receptor was upregulated in sst2-transfected tumors.
|
16218779 |
2005 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Sst2 and sst5 were expressed in 70%, sst1 in 50%, and sst3 and sst4 subtypes only in 15-20% of the tumors.
|
14602773 |
2003 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Moreover, they further indicate that the presence of sst1 and sst3 transcripts might be used as an additional criterion to distinguish between seminoma and nonseminoma tumors.
|
11718451 |
2001 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
RT-PCR analysis showed the presence of sst1, sst2A, and a predominant sst3 messenger RNA (mRNA) expression in the tumor tissue.
|
10770220 |
2000 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
In contrast, cortistatin, sst1, sst4, and sst5 were overexpressed in tumors, while sst3 and sst4 seemed overexpressed in less differentiated tumors.
|
29196939 |
2018 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Expression of sst(3) and sst(5) was observed in 89 and 76% of tumours respectively with highly variable levels. sst(2) mRNA expression was higher in nonfunctional tumours (P < 0.009) and sst5 was higher in pancreatic than in intestinal tumours (P < 0.02).
|
17132755 |
2006 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
The differential expression of sst2/sst3 receptors on gliomas and medulloblastomas has implications for the therapy of these tumours.
|
12047721 |
2002 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
The comparison of SRIF receptor expression between normal tissue and seminoma tumors thus points to a selective loss of sst3 and sst4 mRNA expression in seminomas.
|
10753219 |
2000 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Using reverse transcription-PCR, we investigated gene expression of the five receptors in 47 human normal and cancerous tissues or cell lines from pancreatic and colorectal origin. mRNAs of somatostatin receptor subtypes were detected in 98% of samples, with more than two mRNA subtypes being expressed in 55% of cases. sst1, sst4, and sst5 were heterogeneously expressed in both normal and cancerous tissues; sst3 was rarely or not expressed. sst2 was present in normal pancreatic tissues but was absent in exocrine pancreatic carcinomas and their metastases. sst2 mRNAs were detected in normal colon, sporadic polyadenomas, and 50% of Dukes' stage B and 20% of Dukes' stage C carcinomas but were undetectable in Dukes' stage D carcinomas, hepatic metastases, and adenomas from familial adenomatous polyposis.
|
8620499 |
1996 |
|
Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
By contrast, medulloblastoma tumoral cells exhibited numerous octreotide sensitive somatostatin receptors. sst2 immunocytochemistry demonstrated immunostaining of neuronal cells and neuropile; sst2 and sst3 immunostaining was identified on glioblastoma proliferating vessels endothelial cells and on medulloblastomas tumoral cells.
|
12047721 |
2002 |
|
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Somatostatin decreases COX-2 expression and function in colon cancer cells via activation of sst(3) or sst(5) receptors, and these effects contribute to the inhibitory action of somatostatin on cell proliferation.
|
18587421 |
2008 |
|
Major Depressive Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs.
|
25944848 |
2015 |